Advanced Physical & Analytical Chemistry (445-0-02)

Topic

Magnetic Resonance

Instructors

Songi Han

Meeting Info

Technological Institute MG28: Tues, Thurs 2:00PM - 3:20PM

Overview of class

Magnetic Resonance: In this course, we will cover the fundamentals of Nuclear Magnetic Resonance (NMR) Spectroscopy, the Density Matrix Formalism, the Product Operator Formalism, Relaxation theory, NMR methods to derive molecular dynamics information, basics of biomolecular solution NMR spectroscopy, including assignments and structure determination, fundamentals of solid-state magic angle spinning (MAS) NMR, basics of MAS NMR pulse sequences for assignment and distance determination and application of MAS NMR. This course will also cover the theory and application of dynamic nuclear polarization (DNP). To make this course interesting and accessible to both novice and experts in NMR spectroscopy, we will select for each topic classic and/or representative papers that will accompany each class, so that each student can choose the depth of their study that may go beyond the class material. The class will also include interactive and practical exercises, including the use of Topspin, NMR Data Analysis Software for assignments, Collaborative Computational Project (CCPN) and the solid-state NMR simulation software SIMPSON. The homework will be to read the assigned papers. Each student will be assigned the discussant for a few select topics to post Q&A. The final exam will be a written report on a topic of choice in NMR spectroscopy. This is a graduate level course and will be designed to benefit the student's research directly or indirectly.

Class Materials (Required)

Reading material will be provided at the beginning of class