Advanced Organic Chemistry (415-0-02)

Topic

Medicinal Chemistry

Instructors

Richard Bruce Silverman

Meeting Info

Technological Institute L150: Tues, Thurs 11:00AM - 12:20PM
Location of Midterm TBD: Mon 7:00PM - 9:00PM

Overview of class

Medicinal Chemistry: This is a survey course designed to show how organic chemistry plays a major role in the design, development, and action of drugs. Although concepts of biology, biochemistry, pharmacy, physiology, and pharmacology will be discussed, it is principally an organic chemistry course with the emphasis on physical interactions and chemical reactions and their mechanisms as applied to biological systems. We will see how drugs are discovered and developed; how they get to their site of action; what happens when they reach the site of action in their interaction with receptors, enzymes, and DNA; how resistance occurs; how the body gets rid of drugs, and what a medicinal chemist can do to avoid having the body eliminate them before they have produced their desired effect. The approaches discussed are those used in the pharmaceutical industry and elsewhere for the discovery of new drugs.

Registration Requirements

Prerequisite: organic chemistry or consent of instructor.

Registration in this class is restricted to graduate students in the Chemistry Department. Other students may register with department permission. Please contact chemhelp@northwestern.edu to be placed on a waitlist.

Class Materials (Required)

Title: The Organic Chemistry of Drug Design and Drug Action, 3rd edition
Author: Richard B. Silverman and Mark W. Holladay
Publisher: Academic Press, 2014
ISBN: 9780123820303
Approx price: $100 new or $50 rental

Class Notes

There are problem sets at the end of each chapter and answers in an appendix of the text.

Evening Exam: May 6 7-9 pm

Enrollment Requirements

Enrollment Requirements: Registration in this class is restricted to graduate students in the Chemistry Department. Other students may register with department permission.