Medicinal Chemistry: the Organic Chemistry of Drug Design and Action (316-0-02)
Instructors
Richard Bruce Silverman
Meeting Info
Technological Institute M164: Tues, Thurs 11:00AM - 12:20PM
Location of Midterm TBD: Mon 7:00PM - 9:00PM
Overview of class
This is a survey course designed to show how organic chemistry plays a major role in the design, development, and action of drugs. Although concepts of biology, biochemistry, pharmacy, physiology, and pharmacology will be discussed, it is principally an organic chemistry course with the emphasis on physical interactions and chemical reactions and their mechanisms as applied to biological systems. We will see how drugs are discovered and developed; how they get to their site of action; what happens when they reach the site of action in their interaction with receptors, enzymes, and DNA; how resistance occurs; how the body gets rid of drugs, and what a medicinal chemist can do to avoid having the body eliminate them before they have produced their desired effect. The approaches discussed are those used in the pharmaceutical industry and elsewhere for the discovery of new drugs.
Registration Requirements
Students must have taken CHEM 210-3, 215-3, or CHEM 212-3 with a C- or better to register for this course, or have consent from instructor.
Class Materials (Required)
Title: The Organic Chemistry of Drug Design and Drug Action, 3rd edition
Author: Richard B. Silverman and Mark W. Holladay
Publisher: Academic Press, 2014
ISBN: 9780123820303
Approx price: $100 new or $50 rental
Class Notes
There are problem sets at the end of each chapter and answers in an appendix of the text.
Class Attributes
SDG Good Health and Well-being
SDG Innovation & Infrastructure
Enrollment Requirements
Enrollment Requirements: Students must have taken CHEM 215-3 or CHEM 212-3 or Chem 217-3 with a C- or better to register for this course.